Friday, December 16, 2005

Epoxides, Ethers and alcohols

And so begins the last mad dash for comprehension of the themes and underlying intricacies of organic chemistry 1. These last couple of days I will be reminded of how much I know and don't know about this subject...so let's see what my class notes have to say:

Synthesis of alcohols can be performed in a number of ways

Taking CH3CH2CH2CH3 and adding Br2 (exposed to light or heat to form a bromine radical) and brominating the compound. Follow that up with some KOH in DMF and we will have an alcohol via an SN2 reaction with inversion of stereochemistry.

Acid Catalyzed hydration of alkenes will give us alcohols

Oxymercuration/demercuration will give us a secondary alcohol, with the oxymer/demer steps prohibiting hydride or methide shifts so a relative amount of control is had over the reaction.

Hydroboration and oxidation would be used to get a terminal alcohol formed with BH3 adding to the less substituted carbon...

ok yeah this is dull........

I'll come back to this later.....

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